Phylogenetic analysis

Pre-genomic, classical evolution was based on studying physiological or morphological traits. Today we not only know about DNA, but we can easily obtain the sequences as well. Therefore, evolution is best studied at the molecular level using DNA (or protein) sequences.

Phylogenetic tree

Building a max-likelihood tree

Computing the likelihood given a tree topology

Searching the tree space for a tree with highest likelihood

Confidence measures

Resources for further reading

• https://www.ebi.ac.uk/training/online/courses/introduction-to-phylogenetics/